I came across an issue with a customer earlier today that impacts the installation of NSX 4.1 on a vSphere 8.0 cluster with the new image-based vLCM configured.
The error message you might see when you try to apply a transport node profile to a cluster is as follows:Error: vLCM Config Manager is enabled on this cluster. Applying Transport Node Profile is not allowed. (Error code: 26219)

Normally, you should be able to use a Transport Node Profile to configure a cluster with vLCM enabled using a single image, so what is the problem here?
https://docs.vmware.com/en/VMware-NSX/4.1/installation/GUID-0E4F8397-AD9E-40C8-9B71-B2CEF53A2AD4.html
The issue here is that the cluster is also configured to use a single configuration, which is set at the time of the cluster creation.

If this option is enabled on a cluster, it prevents NSX from configuring each host individually, which it needs to do to install NSX on the cluster, resulting in the error shown above.
To workaround this issue, you must create a new cluster with the option disabled, and move your hosts from the old cluster into the new cluster. Then you will be able to apply the Transport Node Profile to the new cluster.
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